Neuronal Death And Neuroprotection
The brain is a collection of about 10 billion interconnected neurons. Each neuron is a cell that uses biochemical reactions to receive, process and transmit information. Unlike most other cells, neurons are post-mitotic cells and can only partially re-grow after damage. Although neurons are the longest living cells in the body, large numbers of them die during senescence and brain injury.
Scientists hope that by understanding more about the life and death of neurons they can develop new treatments, and possibly even cures, for brain diseases and disorders that affect the lives of millions of people.
The strategies used to protect against neuronal injury or degeneration in the Central Nervous System (CNS) following acute disorders (e.g. stroke or nervous system injury/trauma) or as a result of chronic neurodegenerative diseases (e.g. Parkinson's, Alzheimer's, Multiple Sclerosis) are defined as neuroprotection.
The goal of neuroprotection is to limit neuronal dysfunction/death after injury and attempt to maintain the highest possible integrity of cellular interactions in the brain resulting in an undisturbed neuronal function. This effort is of particular relevance due to the increasing rate of the elderly population.
Tiziana Borsello, Editor Of The Volume Neuroprotection: Methods In Molecular Biology
Published By Humana Press, USA
This book examines current research and methods into neuronal death signaling pathways, with the main aim to give an overview of methods used to study neuronal death and neuroprotection and to offer a really comprehensive step-by-step guide to make clear not just the procedures but also the principles behind the use of it.
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- Publication Date: June 2007
- Pages: 263
- ISBN13: 978-1-58829-666-5
- ISBN10: 1-58829-666-0