Research Interests
The Cargo Strategy As A Key Tool In Neuroprotection
The possibility to target protein complexes and enzymes involved in intracellular signalling pathways by means of cell permeable peptide (CPP) conjugates represents a novel, versatile…
Synaptic Dysfunction
Nowadays it is assumed that AD is a synapse-related pathology leading to synaptic dysfunction and loss, a phenomenon that precedes extensive amyloid deposition in the…
Signalling Pathways In Alzheimer Disease
Alzheimer disease is the most common neurodegenerative disease and the first cause of dementia in the elderly. It is characterized by memory impairment that leads…
Acute Brain Injury And Neuroprotection
In our prevoius study, (Borsello et al, 2003) D-JNKI1 revealed a great neuroprotective effect when administered 6h after the ischemic insult, offering a window of…
Signalling Pathways And Neuroprotection
Upstream JNK activators: We found a rapid and selective activation of MKK7 after NMDA-stress, while the only other JNK activator, MKK4, was unaffected.…
SUMOylation In Acute And Chronic Disease
Small ubiquitin-like modifier (SUMO) is a group of proteins responsible for post translational modifications influencing protein function, localization and stability. Recently, protein Sumoylation has attracted…